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        [9-10]东吴药学论坛 | 格勒诺布尔-阿尔卑斯大学专场学术报告


        报 告 一:Resarch Seminar on Neurodegenerative Diseases

        报告时间:2019910日,9:00 AM


        报告专家:Prof. Frédéric SAUDOU (Ph.D.)

        简介: Dr. Saudou received his Ph.D. from Louis Pasteur University and now is the Director of the Grenoble Institute of Neurosciences (GIN) at the University of Grenoble Alpes, France.

        Research Interest:

        · Studying the normal functions of huntingtin and its role on neuronal functions

        · Dysfunctional consequences of polyGlutamine expansion

        Selected publications:

        1. El-Daher MT, … and Saudou F (2015) Huntingtin proteolysis causes toxicity through dynamin 1 dysregulation. EMBO J. 34 , 2255-71.

        2. Zala D, … and Saudou F (2013) Vesicular glycolysis provides on-board energy for axonal transport. Cell. 152, 479-91. Highlighted in Nat Rev Neurosci, 2013, 14, 156-157; News & Views in Nature, 2013, 495,178-180. (Top 1% ESI)

        3. Keryer G, … and Saudou F. (2011) Ciliogenesis is Regulated by the Huntingtin-HAP1- PCM1 Pathway and is Altered in Huntington Disease. J. Clin Invest, 121, 4372-4382.

        4. Borrell-Pagès M., … Saudou F*. and Humbert S*. (2006) Cystamine and cysteamine increase brain levels of BDNF in Huntington’s disease through HSJ1b and transglutaminase J. Clin. Invest. 116, 1410-1424.

        5. Gauthier LR, … and Saudou F (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell, 118, 127- 138. (Top 1%)



        报 告 二:Resarch Seminar on Nanotoxicology

        报告时间:2019910日,9:00 AM


        报告专家:Prof. Michel SEVE (PharmD, Ph.D., DHDR)



        Prof. Michel SEVE is the Dean of the Faculty of Pharmacy at the University of Grenoble Alpes and the Head of Promethee Proteomic Platform (UGA – Grenoble Hospital), France.

        Research interest:

        · Protein biomarkers research in cancer and other diseases

        · Investigation of post-translational modifications in the control of metabolism in cancer cell

        Selected publications:

        1. Lehmann SG et al. Tubulin beta-3 chain, a new protein biomarker of human skin aging. Oxid Med Cell Longev. 2017; 2017:5140360.

        2. Michelland S et al. A low-molecular color pI markers to monitor on-line the peptides focusing process in OFFGEL fractionation. Electrophoresis. 2017; 38(16):2034-2041.

        3. Martín-Bernabé A. et al. Quantitative proteomic approach to understand metabolic adaptation in non-small cell lung cancer. J Proteome Res. 2014; 13(11):4695-704.

        4. Chenau J et al. The cell line secretome, a suitable tool for investigating proteins released in vivo by tumors: application to the study of p53-modulated proteins secreted in lung cancer cells. J Proteome Res. 2009; 8(10):4579-91.

        5. Chimienti F et al. In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci. 2006; 119( 20):4199-206.

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